Unraveling the TSO500 Workflow: A Deep Dive into TSO500 Workflow Verification

As a software tester in the genomic healthcare technology field, my responsibility is to ensure the smooth functioning of the TruSight Oncology 500 (TSO500) workflow. This involves overseeing the journey of genetic data from the initial sample processing to the generation of comprehensive health reports, using pre-existing sequencing data. My goal is to clarify the process and highlight the critical steps, particularly the seamless integration of data into the Pierian system.

The Initial Phase: Accessioning and Plasma Batch Creation

The process begins with "accessioning," where each blood sample is meticulously cataloged with a unique identifier. This step is akin to assigning a library card to every book, ensuring each sample can be tracked throughout its journey. Although I work with pre-existing sequencing data, I simulate this step to maintain the integrity of the workflow. Following accessioning, we proceed to create plasma batches. While the lab's capacity allows for up to 192 samples in a single run, my testing typically involves 2 to 4 batches. This scaled-down approach enables me to concentrate on the system's efficiency and accuracy in a more controlled environment.

The Role of DRAGEN: A Black Box in the Workflow

DRAGEN (Dynamic Read Analysis for GENomics) is a key component in the analysis of genetic data, known for its speed and accuracy. However, as a software tester, I do not verify the data analysis within DRAGEN. Instead, my role is to ensure that the data reaches the Pierian system correctly. DRAGEN remains a black box to us, meaning we trust the analysis conducted by DRAGEN without direct verification.

Ensuring Data Integrity and Workflow Efficiency

My primary focus is on the following stages:

• Data Analysis: While I don't verify the data analysis within DRAGEN, I monitor the workflow to ensure that the data is being processed and sent out correctly.
• Data Transfer: A critical part of my role is to confirm the successful transfer of data from the DRAGEN platform to the Pierian Clinical Genomics Workspace, maintaining the integrity of the genetic information.
• 
  Report Generation: I evaluate the Pierian platform's ability to produce comprehensive and actionable health reports from the analyzed data.

Integrating Comprehensive Insights: Beyond TSO500

Once the Pierian report is finalized, it is sent to our order management system, where it is merged with other test reports, such as AR-v7 or DefineMBC. These additional tests provide a broader view of the patient's genomic profile, enhancing the personalized care approach.

AR-v7 is a critical test for metastatic prostate cancer, indicating resistance to specific treatments.

DefineMBC offers a comprehensive profile of metastatic breast cancer, analyzing circulating tumor cells (CTCs) and cell-free DNA (cfDNA) to detect genomic alterations that guide personalized treatment strategies.

Conclusion

My role in testing the TSO500 workflow is crucial for ensuring the workflow's accuracy and reliability. By monitoring each step and confirming seamless integration with PierianDx, we help ensure that the platform delivers clinically actionable insights essential for personalized patient care. This blog post aims to provide a clear understanding of the complex process of turning DNA data into a health report from a software tester's perspective, emphasizing the operational side of the workflow and the importance of data integrity in the overall process.

Pitch Perfect or Out of Bounds? A Gamer's Review of Cricket 22 on Switch

Hey fellow cricket enthusiasts and gamers! I've been diving into the digital pitch of Cricket 22 on my Nintendo Switch, and let me tell you, it's been quite the adventure. From the roar of the crowd to the crack of the bat, this game brings the excitement of cricket right to your fingertips. But no game is without its quirks, and I'm here to give you the scoop on what's hot and what's not in Cricket 22.

Test Environment:

• Console: Nintendo Switch
• Version: 1.0.0

Courtesy: Big Ant Studios

My Game Plan:

I mixed up my gameplay with a bit of everything – career mode, quick matches, and the thrill of online challenges. I also put on my detective hat, using some smart testing strategies to really get into the nitty-gritty of the game.

The Detective Work:

•  Boundary Value Analysis: Pushing the game to its limits, I tested everything from epic high scores to the nail-biting finishes.
• Error Guessing: I tried to outsmart the game, predicting where it might trip up, like when I sneak in a quick single or push for a risky double.
• Equivalence Partitioning: I played with all sorts of deliveries and batting shots to see if the game could handle my all-rounder skills.
• State Transition Testing: I switched things up, hopping between game modes and saving my progress to test the game's versatility.
• Exploratory Testing Charter: I zeroed in on specific features like career mode, responsiveness, and those all-important graphics.

Courtesy: Big Ant Studios

The Good, The Bad, and The Glitchy:

What I Loved:

Cricket 22 really does bring the stadium home, with a stellar lineup of teams and competitions. The controls are intuitive, making batting and bowling feel like second nature.

What Needs Work:

1. Career Mode Hurdles: Ever dreamt of leading your team to glory? Well, you might hit a snag. Sometimes your created player just doesn't make the cut for the match lineup, leaving you benched and missing out on the XP action.
2. Batsman Blues: When it comes to quick runs, every second counts. But sometimes, our virtual batsmen seem to be stuck in the mud, leading to some frustrating run-outs.
3. Visuals That Don't Bowl You Over: We all love a game that looks as good as it plays, but Cricket 22's graphics might leave you wanting more, especially when compared to other sports games out there.

The Game Changers:

1. The Infamous System Crash: Imagine this- you've just downloaded some cool extra content, and you're ready to play, but then – bam! – the game crashes, and all that new content vanishes into thin air, along with your precious game data.
2. Player Info Mix-up: You're all set to play as your favorite star, but wait a minute – the stats are all wrong! Yep, some of the player info is about as accurate as a blindfolded umpire's LBW decision.

Wrapping Up:

Cricket 22 has the makings of a great game, but it's like a promising innings cut short by a few unforced errors. The biggies? That dreaded system crash and the player info errors. But hey, nothing that can't be fixed with a bit of elbow grease from the devs.

My Two Cents:

• Let's get those system crashes sorted, pronto!
• A little fact-checking goes a long way – let's update those player stats.
• And while we're at it, a graphics polish wouldn't hurt.

So, what do you think? Have you faced similar issues, or has your experience been smooth sailing? Drop your thoughts and let's chat about all things Cricket 22. Until then, keep your eye on the ball and your gaming spirits high!

A Novice's Tale: Learning the Ropes of Game Testing

As I delve into the world of game testing, I'm discovering the many layers that make this field so intriguing. My journey has led me to test games on platforms like the Nintendo Switch and Steam, each offering unique challenges and learning opportunities. A significant part of my testing experience has been with the charming world of "Animal Crossing: New Horizons" on the Nintendo Switch. The game's delightful characters and immersive environment have provided a rich backdrop for honing my testing skills.

Game testing is far from just leisurely play; it's a critical examination of a game's every aspect to ensure a smooth player experience. For example, during my sessions with "Animal Crossing: New Horizons," I encountered a peculiar issue where my character began to move sluggishly without any input from the controller. This odd behaviour led me to investigate the controller's calibration, revealing it was off-center at rest—a potential compatibility issue between the game and the hardware. Such findings highlight the importance of thorough testing to catch issues that could hinder gameplay enjoyment.

Courtesy: Nintendo

The game testing process is methodical, beginning with drafting a test blueprint. This blueprint considers recent game changes, new supported environments or hardware, potential test scenarios, and any feature modifications. Following the blueprint, the test strategy is executed, which includes setting up the testing environment, identifying and documenting issues, verifying fixes, and ensuring comprehensive coverage through repeated testing. Afterward, the test plan is revisited to confirm that the fixes hold up to our quality standards.

Exploratory testing is a dynamic part of game testing that relies on discovery and intuition rather than a set script. While testing "Animal Crossing: New Horizons," I often relied on my gaming instincts to guide me through the game's vibrant world, uncovering issues that structured testing might miss.

In addition to exploratory testing, other essential testing types ensure a game's quality, such as functionality testing, compatibility testing, progression testing, and regression testing. Each plays a vital role in the game testing process.

Game testing is a complex field that blends technical skills with an understanding of the player experience. It's a challenging yet rewarding endeavour that significantly contributes to creating games that resonate with players worldwide. As I continue my journey in game testing, I eagerly anticipate the learning experiences ahead and the chance to contribute to crafting enjoyable and engaging gaming experiences.